Research Associate in Carbohydrate Chemistry/Chemical Biology _FILLED
Job Reference : S&E-14815
Location : Manchester Institute of Biotechnology and Department of Chemistry, University of Manchester
Closing Date: 03/12/2019
Salary : £ Grade 6 £32,816 to £40,322 per annum
Employment Type : Fixed Term
Faculty / Organisational Unit : Science & Engineering
Division : Chemistry
Glycoscaminoglycan oligosaccharides (GAGs) are essential to many critical biological processes, including cell-differentiation, cancer, bacterial and viral infections and inflammation, so there is major interest in advancing our understanding of the chemical biology and biomolecular interactions of these structures. This project aims to develop a platform of synthetic GAG structures to interrogate the H/HS interactome, which will provide unprecedented details of GAG biomolecular interactions It is a collaboration between University of Manchester, Department of Chemistry and the School of Chemistry, University of Glasgow; there will be an allied biophysical PDRA positon at the University of Glasgow. Applications are invited for the postdoctoral position at the University of Manchester, which aims to synthesise carbohydrate (oligosaccharide) targets as tools for chemical biology.
This Manchester position will involve the synthesis of GAG oligosaccharides and conjugates and their use for liposome labelling and other nanoscale applications, such as chemical biology tools for native and mutant GAG-binding proteins. The work will develop chemical and biocatalytic methods for conjugation. This post will be primarily based in the synthetic chemistry labs in the Manchester Institute of Biotechnology (http://www.mib.ac.uk), an internationally-leading state-of-the-art building for research in interdisciplinary biologically-related science. The successful applicant will be part of a team involving carbohydrate synthesis (Gardiner: www.gardinergroup.org.uk), liposome applications and biophysical studies (Webb: www.webblab.org), and biocatalytic carbohydrate modification (Flitsch: www.flitschlab.com). The project is ideally-suited for applicants keen to explore multidisciplinary applications, including biophysical studies using liposomes, protein science and also exploring and evaluating biocatalytic oligosaccharide modifications. The Glasgow position (separately advertised through UoG, supervised by Dr S Magennis) will involve single-molecule spectroscopic method development and applications. The Manchester PDRA will have regular contacts within the UoG team and be involved in project planning meetings.
Applicants should have a PhD (or equivalent) in synthetic or bioorganic chemistry / chemical biology and must have experience in carbohydrate synthetic work. Experience of labelling chemistry and/or multidisciplinary work would be an advantage, though not essential. The appointee must have demonstrated the ability to produce leading research outputs. Evidence of managing research projects previously would be an advantage.
The School of Chemistry is strongly committed to promoting equality and diversity, including the Athena SWAN Charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff to achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.
Informal enquiries about the project, vacancy shortlisting and interviews:
Name: Dr John Gardiner
Tel: 0161 850 2004
Tel: 0161 275 4499
This vacancy will close for applications at midnight on the closing date
Further Particulars and Full Job Description at: