121. Jeanerret, R. A.; Dalton, C. E.; Gardiner J. M. "Synthesis of Heparan Sulfate- and Dermatan Sulfate-Related Oligosaccharides via Iterative Chemoselective Glycosylation Exploiting Conformationally-Disarmed [2.2.2] L-Iduronic Lactone Thioglycosides." J. Org. Chem. 2019 in press. https://pubs.acs.org/doi/abs/10.1021/acs.joc.9b01594


120. Issa, I. S.; Toogood, H. T.; Johannisen, L. O.; Scrutton, N. S.; Gardiner, J. M.  "C3 and C6 Modification-specific OYE biotransformations of synthetic carvones and sequential BVMO chemoenzymatic synthesis of chiral caprolactones." Chem.-Eur. J.  2019, 25, 2983-2988. http://dx.doi.org/10.1002/chem.201805219


119. Mkadmha, A. M.; Rami Y. Morjan, R. Y.; James Raftery, J;  Awadallah, A. M.; Gardiner, J. M. "Synthesis, Structural Characterization, and Computational Study of New (E)-N'-(3,4-dimethoxybenzylidene)furan-2-carbohydrazide." Arab. J. Chem. in press  2019https://doi.org/10.1016/j.arabjc.2018.12.008

118. Binto, S.; Walmsley, C.; Garvey, E. P.; Slater, M. J.; Berrisford, D. J.; Gardiner, J. M. "Evaluation of Neomycin Analogues for HIV-1 RRE RNA Recognition Identifies Enhanced Activity Simplified Neamine Analogues". Bioorg. Med. Chem. Lett. 2019, 29, 339-341. https://doi.org/10.1016/j.bmcl.2018.11.004





117. Morjan, R. Y.; El-KurdiS. M.; Azarah, J. N.; Eleiwa, N. A.; Abu-Teim, O. S.; Awadallah, A. M.; Raftery, J.;  Gardiner, J. M. "Inversion dimers dominate the crystal packing in the structure of trimethyl citrate (trimethyl 2-hy­droxy­propane-1,2,3-tri­carboxyl­ate)." Acta Cryst. 2018, E74, 1362-1365. DOI: https://doi.org/10.1107/S2056989018011222


116. Ní Cheallaigh, A.; Toogood, H.; Mansell, D. J.; Lygidakis, A.; Tait, S.; Scrutton, N. S.; Gardiner, J. M. "Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway" J. Nat. Prod. 2018, 81, 1546–1552. DOI: 10.1021/acs.jnatprod.7b01026

115. Currin, A. Dunstan, M.; Johannissen, L. O.; Hollywood, Katherine; Vinaixa, M.; Jervis, A.; Swainston, N.; Rattray, N. J. W.; Gardiner, J. M.; Kell, Douglas; D.; Takano, E.; Toogood, H. S.; Scrutton, N. S. "Engineering the ‘Missing Link’ in Biosynthetic (–)-Menthol Production: Bacterial Isopulegone Isomerase" ACS Catal. 2018, 8, 2012–2020. DOI: 10.1021/acscatal.7b04115


114. Potter, G. T.; Guazelli, L.; Jayson, G. C.; Miller, G. J.; Gardiner, J. M. “Synthesis of 1,3,4,6-Tetra--acetyl-2-azido-2-deoxy-α,β-D-glucopyranose using the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate.” Ch. 18. Carbohydrate Chemistry: Proven Synth. Methods, Vol. 4, Sept 2017, CRC Press, ISBN 9781498726917.

113. Karuppiah, V.; Ranaghan, K. E.; Leferink, N. G. H.; Johannissen, L. O.; Shanmugam, M.; Ní Cheallaigh, A.; Bennett, N. J.; Kearsey, L. J.; Takano, E.; Gardiner, J. M.; van der Kamp, M. W.; Hay, S.; Mulholland, A. J.; Leys, D.; Scrutton, N. S. “Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.”ACS Catal. 2017, 7, 6268−6282. DOI: 10.1021/acscatal.7b01924.

112. Hunter, A.; Oni, Y. I.; Dodd, H. T.; Raftery, J.; Gardiner, J. M.; Uttley, M. “Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones.” BBA - Molecular and Cell Biology of Lipids 2017, 1862, 939-945. doi: 10.1016/j.bbalip.2017.06.003. (IF. 4.77)

111. Waller, J.; Toogood, H. S.; Karuppiah, V.; Rattray, N. J. W.; Mansell, D. J.; Leys, D.; Gardiner, J. M.; A. Fryszkowska, A.; Ahmed, S.; Bandichhor, R.; Reddy, G. P.; Scrutton, N. S. “Structural insights into the ene-reductase synthesis of Profens. Org. Biomol. Chem. 2017, 15, 4440-4448. doi: 10.1039/c7ob00163k.

110. Heyes, D. J.; Hardman, S. J. O.; Mansell, D.; Ní Cheallaigh, A.; Gardiner, J. M.; Johannissen, L. O.; Greetham, G. M.; Towrie, M.; Scrutton, N. S. "Excited State Properties of Protochlorophyllide Analogues and the Implications for Light Driven Synthesis of Chlorophyll." J. Phys. Chem. B 2017, 1312–1320.

109. Abid, S. M. A.; Aslam, S.; Zaib, S.; Bakht, S. M.; Ahmad, M.; Athar, M. M.; Gardiner, J. M.; Iqbal, J. “Pyrazolobenzothiazine-based carbothioamides asnew structural leads for the inhibition of monoamine oxidases: design, synthesis, in vitro bioevaluation and molecular docking studies.” Med. Chem. Commun. 2017, 8, 452-464.


108  Dalton,C. E.; Quinn,S. D.; Rafferty,A.; Morten,M. J.; Gardiner, J. M.; Magennis, S. W. “Single-molecule fluorescence detection of a synthetic heparan sulfate disaccharide.” 2016, 3442-3446. DOI: 10.1002/cphc.201600750.

107. Lygidakis, A.; Ní Cheallaigh, A.; Karuppiah, V.; Hoeven, R.; Leys, D.; Gardiner, J. M.; Toogood, H. S.; Scrutton, N. S. “Pinpointing a mechanistic switch between ketoreduction and ‘ene’-reduction in short chain dehydrogenases/reductases.” Angew. Chemie. Int. Ed. 2016, 55, 9596 –9600. DOI: 10.1002/ange.201603785.

106. Ní Cheallaigh, A.; Potter, G. T.; Gardiner, J. M.; Miller, G. J. “Preparation of Methyl 1,2,3,4-tetra-O-acetyl-β-D-glucopyranuronate.” Org. Synth. 2016, 93, 200-209. DOI: 10.1002/0471264229.os093.15

105. Avizienyte, E.; Cole, C. L.; Rushton, G.; Miller, G. J.; Bugatti, A.; Presta, M.; Gardiner, J. M.; Jayson, G. C. “Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo.” PLOSOne 2016, 11(8), e0159739. DOI: 10.1371/journal.pone.0159739.

104. Toogood, H. S.; Tait, S.; Jervis, A.; Ní Cheallaigh, A.; Humphreys, L.; Takano, E.; Gardiner, J. M.; Scrutton, N. S. “Natural Product Biosynthesis in Escherichia coli: Mentha Monoterpenoids.” In Methods in Enzymol., Elsevier,  2016, DOI: 10.1016/bs.mie.2016.02.020

103. Potter, G. T.; Miller, G. J.; Jayson, G. C.; Gardiner, J. M. “An Updated Synthesis of the Diazo-Transfer Reagent Imidazole-1-sulfonyl Azide Hydrogen Sulfate.” J. Org. Chem. 2016, 3441-3446.

102. Althumayri, K.;  Harrison, W. J.; Shin, Y.; Gardiner,  J. M.; Caziraghi, C.; Budd, P. M.; Bernardo, P.; Clarizi, G.; Jansen, J. C. “The influence of graphene and other nanofillers on the gas permeability of the high-free-volume polymer PIM-1.” Philosophical Transactions of the Royal Society A, 2016, 374: 20150031.

101. Mkadmh, A. M.; Abu-Shanab, A. M.; Morjan, R. Y.; Safi, Z.; Pritchard, R. G.; Gardiner, J. M. “Synthesis, Crystallographic Characterization and Density Functional Study of Novel Spoke-Molecular Tetravalent ethyltriphenylphosphorous Dibromide”.  Chem. Sci. Trans. 2016, 5, 674-686.

100. Quinn,S. D.; Dalton,C. E.; Jeanneret, R. A.; Gardiner,J. M.; Magennis, S. W. “Single-molecule studies of fluroescently-labeled polysaccharides.” Biophys. Journal 2016, 110, Suppl. 1, 636a. Doi: 10.1016/j.bpj.2015.11.3404


99. Althumayri, K.;  Harrison, W. J.; Shin, Y.; Gardiner,  J. M.; Caziraghi, C.; Budd, P. M.; Bernardo, P.; Clarizi, G.; Jansen, J. C. “The influence of graphene and other nanofillers on the gas permeability of the high-free-volume polymer PIM-1.” Philosophical Transactions of the Royal Society A, 2016, 374: 20150031.


98. Miller, G. J.; Broberg, K. R.; Rudd, C.; Helliwell, M. R.; Jayson, G. C.; Gardiner, J. M. A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides.” Org. Biomol. Chem. 2015, 13, 11208-

97. DOI: 10.1039/C5OB01706H 97. Hansen, S. U.; Miller, G. J.; Cliff, M. J.; Jayson, G. C.; Gardiner, J. M. “Making the longest sugars: a chemical synthesis of heparin-related [4]n oligosaccharides from 16-mer to 40-mer.” Chemical Science 2015, 6, in press. DOI: 10.1039/C5SC02091C

96. Jayson, G. C.; Hansen, S. U.; Miller, G. J.; Cole. C.; Rushton, G.; Avizienyte, E.; Gardiner, J. M. “Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.” Chem. Commun. 2015, in press DOI: 10.1039/C5CC05222J

95.  Potter, G. T.; Miller, G. J.; Jayson, G. C.; Gardiner, J. M. “Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids.” Tetrahedron Lett. 2015, 56, 5153-5156. doi:10.1016/j.tetlet.2015.05.054

94. Toogood, H. S.; Ní Cheallaigh, A.; Tait, S.; Mansell, D.; Jervis, A.; Lygidakis, A.; Humphreys, L.; Takano, E.; Gardiner, J. M.; Scrutton, N. S. “Enzymatic Menthol Production:  One-pot Approach Using Engineered Escherichia coli.” ACS Synthetic Biology 2015, in press DOI: 10.1021/acssynbio.5b00092

93. Hansen, S. U.; Dalton, C. E; Baráth, M.; Kwan, G.; Raftery, J.; Jayson, G. C.; Miller, G. J.; Gardiner, J. M. “Synthesis of L‐iduronic acid derivatives via [3.2.1] and [2.2.2] L‐iduronic lactones from bulk glucose-derived cyanohydrin hydrolysis: A reversible conformationally-switched superdisarmed/rearmed lactone route to heparin disaccharides.” J. Org. Chem. 2015, 80, 3777-3789. DOI: 10.1021/jo502776f

92. Baráth, M.; Hansen, S. U.; Dalton, C. E.; Jayson, G. C.; Miller, G. J.; Gardiner, J. M. “Modular synthesis of a heparin-related tetra-, hexa- and octasaccharides with differential O-6 protections: Programing for regiodefined 6-O-modifications.” Molecules 2015, 20, 6167-6180.

91. Morjan, R. Y.; El-Attar, N.; Abu-Tiem, O.; Ulrich, M.; Awadallah, A. M.; Mkadmh, A. M.; Elmanama, A. A.; Raftery, J.; Abu-Awwad, F. M.; Yaseen, Z. J.; Elqidra, A. F.; Gardiner, J. M. “Synthesis, antibacterial, and QSAR evaluation of 5- oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles.” Bioorg. Med. Chem. Lett. 2015, 25, 4024-4028. doi:10.1016/j.bmcl.2015.04.070 

90. Ahmad, M; Aslam, S.; Rizvi, S. U.; Muddassar, M.; Ashfaq, U. A.; Montero, C.; Ollinger, O.; Detorio, M.; Gardiner, J. M.*; Schinazi, R. F. “Molecular docking and anti-viral screening of N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides.” Bioorg. Med. Chem. Lett. 2015, 25, 1348-1351. http://dx.doi.org/10.1016/j.bmcl.2015.01.007



89. Jayson, G. C.; Miller, G. J.; Hansen, S. U.; Barath, M.; Gardiner, J. M.; Avizienyte, E.  “The development of anti-angiogenic heparan sulfate oligosaccharides.”  Biochem. Soc. Trans. 201442, 1596-1600.

88. Morjan, R. Y.; Mkadmh, A. M.; Beadham, I.;  Elmanama, A. A.; Mattar, M. R.; Raftery, J.; Pritchard, R. G.; Adel M. Awadallah, A. M.; Gardiner, J. M. “Antibacterial activities of novel synthetic N-acylhydrazones of nicotinic acid hydrazide and their conversion into N-acetyl-1,3,4-oxadiazoles.”  Bioorg. Med. Chem. Lett. 201424, 5796-5800. DOI: 10.1016/j.bmcl.2014.10.029

87. Miller, G. J.; Hansen, S. U.; Baráth, M.; Johannessen, C.; Blanch, E. W.; Jayson, G. C.; Gardiner, J. M. “Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy.” Carbohydr. Res. 2014, 400, 44-53. DOI: 10.1016/j.carres.2014.06.026 

86. Morjan, R. Y.; Qesta, B. S.; Al-Shayyah, H. T.; Gardiner, J. M.; Thaher, B. A. A.; Awadallah, A. M. “Reaction of Nitrilimines with 2-Aminopicoline, 3-Amino-1,2,4-triazole, 5-Aminotetrazole and 2-Aminopyrimidine.” Int. J. Org. Chem. 20144, 201-207. DOI: 10.4236/ijoc.2014.43023

85. Kadirvel, M.; Fanimarvasti, F.; Forbes, S.; McBain, A.; Gardiner, J. M.;* Brown, G. D.;* Freeman, S.* “Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-Fluoro-DPD; a novel potent inhibitor of AI-2 signalling.” Chem. Commun. 201450, 5000 - 5002. DOI:10.1039/C3CC49678C

84. Aslam, S.; Zaib, S.; Ahmad, M.; Gardiner, J. M.; Ahmad, A.; Hameed, A.; Furtmann, N.; Gütschow, M.; Bajorath, J.; Iqbal, J. “Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors.”  Eur. J. Med. Chem. 2014, 78, 106-117. DOI: 10.1016/j.ejmech.2014.03.035



83. Aslam, S.; Atloob, M.; Athar, M. M.; Ashfaq, U. A.; Gardiner, J. M.; Montero, C.; Detori, M.; Parvez. M; Schinazi, R. F. “Synthesis, molecular docking and antiviral screening of novel N’-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl) acetohydrazides.” Medicinal Chemistry Research 201323, 2930-2946. DOI 10.1007/s00044-013-0879-7

82. Hansen, S. U.; Miller, G. J.; Cole. C.; Rushton, G.; Avizienyte, E.; Jayson, G. C.; Gardiner, J. M.  “Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies.” Nature Communications 2013. DOI: 10.1038/ncomms3016.

81. Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.-i; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S. M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Hansen, S. U.; Jayson, G. J.; Miller, G. J.; Gardiner, J. M.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M. J. Am. Chem. Soc. 2013135, 11032-11039. DOI: 10.1021/ja4018682

80. Miller, G. J.; Hansen, S. U.; Cole. C.; Avizienyte, E.; Rushton, G.; Jayson, G. C.; Gardiner, J. M.  “Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions.” Chemical Science 20134, 3218-3222. DOI: 10.1039/C3SC51217G 

79. Morjan, R. Y.; Mkadmh, A. M.; Abu-Awwad, F. M.; Helliwell, M.; Awadallah, A.M.; Gardiner, J. M. “Synthesis, Structural Characterization, and Computational Study of Novel (E)-N’-(1-p-tolylethylidene)furan-2-carbohydrazide.” J. Mol. Struct. 20131051, 345-353. DOI: 10.1016/j.molstruc.2013.08.008

78. Mansell, D.; Toogood, H. S.; Waller, J.; Hughes, J. M. X.; Levy, C.; Gardiner, J. M.; Scrutton, N. S. Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum.” ACS Catalysis 20133, 370-379. EScholar ID: 197146 DOI: 10.1021/cs300709m

77. Hansen, S. U.; Miller, G. J.; Jayson, G. C.; Gardiner, J. M. “First Gram-scale Synthesis of a Heparin-related Dodecasaccharide.” Orglett 201315, 88-91. EScholarID: 197133   DOI: dx.doi.org/10.1021/ol303112y 

76. Ahmad, M.; Siddiqui, H. L.; Gardiner, J. M.; Parvez. M; Aslam, S. “Synthesis and antioxidant studies of novel N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides.” Medicinal Chemistry Research 2013, 22, 794-805. EScholarID: 175760     DOI: 10.1007/s00044-012-0062-6 



75. Morjan, R. Y.; Thaher, B. A. A.; Schollmeyer, D.; Awadallah, A. M.; Gardiner, J. M. “(Z)-1-Chloro-1(2-(2-nitrophenyl)hydrazono)propan-2-one” Acta Cryst E:Structure Reports Online 201269, o72. EScholarID:     DOI: http://dx.doi.org/10.1107/S1600536812049938

74. Hansen, S. U.; Miller, G. J.; Barath, M.; Broberg, K. R.; Avizienyte, E.; Helliwell, M.; Raftery, J.; Jayson, G. C.; Gardiner, J. M. “Synthesis and        Scalable Conversion of L-Iduronamides to Heparin-Related Di- and Tetrasaccharides.” J. Org. Chem. 201277, 7823–7843. EScholarID: 92344     http://dx.doi.org/10.1021/jo300722y    

73. Fryszkowska, A.; Toogood, H. S.; Mansell, D.; Stephens, G. M.; Gardiner, J. M.; Scrutton, N. S. “A surprising observation that oxygen can affect the product enantiopurity of an enzyme catalysed reaction“ FEBS2012279, 4160-4171.   EScholarID: 175771  DOI: 10.1111/febs.12008

72. Ferreras, C.; Rushton, G.; Cole, C.; Babur, M.; Telfer, B. A.; van Kuppevelt, T. H.; Gardiner, J. M.; Williams, K. J.; Jayson, G. C.; Avizienyte, E. “Endothelial Heparan Sulfate 6-O-sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to FGF2 and VEGF.” J. Biol. Chem. 2012, 287, 36132-32146.  EScholarID: 175765     DOI: 10.1074/jbc.M112.384875

71. Heyes; D. J.; Hardman; S.; Mansell; D.; Gardiner; J.; Scrutton, N. S. “Mechanistic reappraisal of early stage photochemistry in the light-driven enzyme protochlorophyllide oxidoreductase.” PLOSOne, 20127, e45642.  EScholarID: 175764    doi:10.1371/journal.pone.0045642


70. Toogood,  H. S.; Mansell, D.; Gardiner, J. M.; Scrutton, N. S. 2012, Vol 7, pp216-255. “Enantioselective bioreduction of carbon-carbon double bonds.” Turner, N. J. (Ed.), Comprehensive Chirality. Elsevier. ISBN: 978-0-08-095168-3


69. Miller, G. J.; Gardiner, J. M. “A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation.” Tetrahedron Lett. 2011, 52, 3216-3218. EScholarID: 148613   doi:10.1016/j.tetlet.2011.04.047

68. Toogood, H. S.; Fryszkowska, A.; Hulley, M.; Sakuma, M.; Mansell, D.; Stephens, G. M.; Gardiner, J. M.; Scrutton, N. S. “A site-saturated mutagenesis study reveals that residues 181 and 184 influence ligand binding, stereochemistry and oxime formation in pentaerythritol tetranitrate reductase.” ChemBioChem, 2011, 12, 738-749.  EScholarID: 148611   doi: 10.1002/cbic.201000662

67. Fryszkowska, A.; Toogood, H. S.; Sakuma, M.; Stephens, G. M.; Gardiner, J. M.; Nigel S. Scrutton, N. S. “Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with α,β-unsaturated nitroolefins”    EScholarID: 148614    Catal. Sci. Technol. 2011, 1, 948-956. DOI:10.1039/C0CY00092B



66. Miller, G. J.; Gardiner, J. M. “Adaptable Synthesis of C-Glycosidic Multivalent Carbohydrates and Succinamide-linked Derivatisation.” OrgLett 2010, 12, 5262-5265. EScholarID: 94691      DOI: 10.1021/ol102310x

65. Satelle, B.; Hansen, S. U.; Gardiner, J.; Almond, A. “Free Energy Landscapes of Iduronic Acid and Related Monosaccharides.” J. Am. Chem. Soc. 2010, 132, 13132-13134.   DOI: 10.1021/ja1054143

64. Cole, C. L.; Hansen, S. U.; Barath, M.; Rushton, G.; Gardiner, J. M.; Avizientye, E.;  Jayson, G. C. “Synthetic Heparan Sulfate Oligosaccharides Inhibit Endothelial Cell Functions Essential for Angiogenesis.” PLOS One, 2010, 5, e11164. EScholarID: 92344      DOI: 10.1371/journal.pone.0011644.

63. Hulley, M. E.; Toogood, H. S.; Fryszkowska, A.; Mansell, D.; Stephens, G. M.; Gardiner, J. M.; Scrutton, N. S. “Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries.” ChemBioChem, 2010, 11, 2433-2447. [INSIDE COVER HIGHLIGHT ARTICLE] EScholarID: 94693       DOI: 10.1002/cbic.201000527

62. Toogood, H. S.; Gardiner, J. M.; Scrutton, N. S. “Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases.” ChemCatChem, 2010, 2, 892-914. [REVIEW] EScholarID: 92345        DOI: 10.1002/cctc.201000094

61. Kadirvel, M.; Stimpson, W. T; Moumene-Afifia, S.; Arsic, B.; Glynn, N.; Halliday, N.; Williams, P.; Gilbert, P.; McBain, A. J.; Freeman, S.; Gardiner, J. M.* “Synthesis and bioluminescence-inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomer.” Bioorg. Med. Chem. Lett. 2010, 20, 2625-2628.   EScholarID: 92347         DOI: 10.1016/j.bmcl.2010.02.064


60. Fryszkowska, A.; Toogood, H. S.; Sakuma, M.; Gardiner, J. M.; Stephens, G. M.; Scrutton, N. S., “Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation.” Adv. Synth. Fatal. 2009, 351, 2976-2990. EScholarID: 92346

59. Hansen, S. U.; Barath, M.; Salameh, B. A.; Pritchard, R. G.; Stimpson, W. T.; Gardiner, J. M.*;  Jayson, G. C. “Scalable synthesis of L-iduronic acid derivatives via stereocontrolled cyanohydrin reaction for synthesis of heparin-related disaccharides.” OrgLett 2009, 11, 4528-4531.    EScholarID: 60868    DOI: 10.1021/ol901723m



58. H. S. Toogood, A. Fryszkowska, V. Hare, K. Fisher, A. Roujeinikova, D. Leys, J. M. Gardiner, G. M. Stephens, N. S. Scrutton, “Structure-based insight into the asymmetric bioreduction of the C=C double bond of a,β--unsaturated nitroalkenes by pentaerythritol tetranitrate reductase.” Adv. Synth. Catal.  2008, 350, 2789.  EScholarID: 14401

57. A. Fryszkowska, K. Fisher, John M. Gardiner, Gill M. Stephens, “Highly Enantioselective Reduction of β,β-Disubstituted Aromatic Nitroalkenes Catalyzed by Clostridium sporogenes.” J. Org. Chem. 2008, 4295–4298.   EScholarID: 60854

56. H. Korbekandi, P. Mather, J. Gardiner, G. Stephens “Reduction of aliphatic nitro groups using an obligately anaerobic Whole cell biocatalyst” Enzyme and Microbial Technology, 2008, 42, 308-314.

55. M. F. Rodriquez Martinez, N. Kelessidou, Z. Law, J. M. Gardiner, G. M. Stephens, “Effect of solvents on obligately anaerobic bacteria.” Anaerobe, 2008, 14, 55-60. 


54. G. L. Brown, J. M. Gardiner, A. d’Emanuele, D. Attwood, R. Gibb “Synthesis and characterization of shape-persistent polyphenylene dendrimers.” Polymer Prep. 2006, 47, 660-661.   EScholarID: 60846


53. J. M. Gardiner, N. R. Panchal, W. T. Stimpson, G. J. Ellames, J. M. Herbert "Stereoselective Synthesis of 1,2-13C2-L-Fucose, 1,2-13C2-Fucono-g-lactone and 1,2-13C2-Fucono-g-lactol from Non-sugar Starting Material." Synlett 2005, 2685-2687.  EScholarID: 1a465

52. O. Dipeolu, J. M. Gardiner, G. M. Stephens "Biocatalytic amide reduction using Clostridium sporogenes." Biotechnology Lett. 2005, 27, 1803-1807.  EScholarID: 60844

51. S. Freeman, J. M. Gardiner "A brief history of medicine; Review of Life saving drugs: the elusive magic bullet (by John Mann)"." Chem. & Ind. 2005, 28-29.

50. A. Lenourry, J. M. Gardiner, G. M. Stephens “Hydrogenation of C–C double bonds in an ionic liquid reaction system using the obligate anaerobe, Sporomusa termitida.” Biotechnology Lett. 2005, 27, 161–165.  EScholarID: 14397


49. H. Li, P. Williams, J. Micklefield,  J. M. Gardiner, G. M. Stephens "A dynamic combinatorial screen for novel imine reductase activity."  Tetrahedron 2004, 60, 753-758.   EScholarID: 1a84

48. J. M. Gardiner, R. Mills, T. Fessard "Synthesis of model ring systems related to C10-C18 analogues of the Mycalamides/Theopederins." Tetrahedron Lett. 2004, 45, 1215-1217.  EScholarID: 14391


47. J. M. Gardiner, P. D. Crewe, G. E. Smith, K. T. Veal "Novel Isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction", Chem. Commun. 2003, 618-619.  EScholarID: 1a85

46. J. M. Gardiner, P. D. Crewe, G. E. Smith, K. T. Veal, R. G. Pritchard, J. E. Warren "Synthesis, stereostructure and conformations of novel bi- and trifunctional (+)-isomenthone derivatives." Org.Lett. 2003, 5, 467-470.   EScholarID: 1a9052

45. J. M. Gardiner, A. D. Goss, T. Mahid, A. D. Morley "Synthesis of novel 2,2- and 1,1-linked dimeric ‘Head-to-head’ N-alkoxybenzimidazoles." Tetrahedron Lett. 2003, 44, 511-513.  EScholarID: 14388


44. J. M. Gardiner, A. D. Goss, T. Mahid, A. D. Morley, R. G. Pritchard, J. E. Warren "Versatile synthesis of N-alkoxybenzimidazoles and N-alkoxypyrimidazoles." Tetrahedron Lett. 2002, 43, 7707-7710.  

43. J. M. Gardiner, P. E. Giles, M. M. L. Martin "Approach towards C12-oxo analogues of the side chain of pumiliotoxin B/allopumiliotoxin 339A and B." Tetrahedron Lett. 2002, 43, 5415-5418.

42. J. M. Gardiner, P. Mather, R. Morjan, R. G. Pritchard, J. E. Warren, M. L. Cooper, A. El-Rahman S. Ferwanah and O. S. Abu-Tiem "Synthesis and structure of 2-aryl-5,5-disubstituted-1,3-dioxanes and conversion into chiral (1,1,1-trishydroxymethyl) methane derivatives." Tetrahedron Lett. 2002, 43, 2091-2094.

41. J. M. Gardiner, “Synthesis of enantiomerically pure non-carbohydrate compounds”, Specialist Periodical Reports, Carbohydrate Chemistry, 2002, vol. 33, ch. 24, 375-410 [review].


40. J. M. Gardiner, J. Procter "Synthesis of N-alkoxybenzimidazoles with differentiated C2 and 0-substituents." Tetrahedron Lett. 2001, 42, 5109-5111.

39. J. M. Gardiner "Synthesis of enantiomerically pure non-carbohydrate compounds", Specialist Periodical Reports, Carbohydrate Chemistry, 2001, vol. 32, ch. 24, 353-395.


38. J. M. Gardiner, Strategies for the synthesis of complex carbohydrates, in 'The Chemical Synthesis of Natural Products', ed. K. J. Hale, Sheffield Academic Press, 2000, pp. 1-39.

37. J. M. Gardiner, Specialist Periodical Reports, Carbohydrate Chemistry, 2000, vol. 31, ch. 22, 322-339.

36. J. M. Gardiner, Specialist Periodical Reports, Carbohydrate Chemistry, 2000, vol. 31, ch. 24, 347-384.


35. J. M. Gardiner, J. H. Chughtai, I. H. Sadler "Synthesis and Proof of Stereostructure of a New (+)- Isomenthone-derived Homochiral 1,3-Diol."Tetrahedron: Asymmetry 1998, 9, 599-606.

34. J. M. Gardiner, S. E. Bruce "Unexpected Diastereoselectivity in AD of an L-Proline-Derived 1,1- Disubstituted Alkene." Tetrahedron Lett. 1998, 39, 1029.

33. J. M. Gardiner Specialist Periodical Reports, Carbohydrate Chemistry, 1998, vol. 30, ch. 22, 329-349.


32. J. M. Gardiner Specialist Periodical Reports, Carbohydrate Chemistry, 1998, vol. 30, ch. 24, 354-400.

31. J. M. Gardiner "Therapeutic Potential of Synthetic Multivalent Carbohydrates" Expert Opinion in Investigational Drugs 1998, 7, 405-419.

30. J. H. Chughtai, J. M. Gardiner, S. G. Harris, S. Parsons, D. W. H. Rankin, C. H Schwalbe "New Homochiral Ketocalcohols from Aldol Reactions of Isomenthone and Reversal of Diastereoselectivity." Tetrahedron Lett. 1997, 38, 9043.

29. T. M. Evans, J. M. Gardiner, N. Mahmood, M. Smis "Structure-Activity Relationships of Anti-HIV- 1 N-Alkoxy and N-Allyloxy-Benzimidazoles." Bioorg. Med. Chem. Lett. 1997, 7, 409.

28. J. M. Gardiner Specialist Periodical Reports, Carbohydrate Chemistry, 1997, vol. 29, Ch. 22, pp 324-345.

27. J. M. Gardiner Specialist Periodical Reports, Carbohydrate Chemistry, 1997, vol. 29, Ch. 24, pp 357-404.

26. J. M. Gardiner, M. Nørret, I. H. Sadler "Diastereospecific Dihydroxylation and Highly Efficient Kinetic Resolution of cis/trans-2,6-Dimethylbenzlidene Cyclohexane." J. Chem. Soc., Chem. Commun. 1996, 2709.

25. J. M. Gardiner, M. Nørret, I. H. Sadler "Diastereospecific Epoxidation/AE Kinetic Resolution of cis/trans-2,6-Dimethylbenzlidene Cyclohexane and Solution Conformation of 4,8-Dimethyl-2- phenyl-1- oxaspiro[2.5]octane." Tetrahedron Lett. 1996, 37, 8447-8450.

24. I.D. Spiers, C.J.Barker, S.-K Chung, Y.-T. Chang, S. Freeman, J. M. Gardiner, P. H. Hirst, P. A. Lambert, R. H. Mitchell, D. R. Poyner, C. H. Schwalbe, A. W. Smith, K. R. H. Solomons, "Synthesis and iron binding studies of myo-inostiol 1,2,3-trisphosphate and D/L-myo-inositol 1,2- bisphosphate, and iron-binding studies of all myo-inositol tetrakisphosphates" Carbohydrate Res. 1996, 282, 81.

23. J. K. Chipman, S. Barcelo, A. Gescher, J. M. Gardiner "Cytochrome P450 2E1-mediated mechanism of antigenotoxicity of the broccoli constituent sulforaphane" Carcinogenesis 1996, 17, 277-282.

22. M. D. Coleman, M. S. Ogg, J. L. Holmes, J. M. Gardiner, D. P. Jacobus, "Studies on the differential sensitivity between diabetic and nondiabetic human erythrocytes to monoacetyl dapsone hydroxylamine-mediated methemoglobin formation in-vitro." Environmental Toxicol. and Pharmacol. 1996, 1, 97-102.

21. M. D. Coleman, K. K. Pahal, J. M. Gardiner "The effect of acetylation and deacetylation on the disposition of dapsone and monoacetyl dapsone hydroxylamines in human erythrocytes in vitro." J. Pharm. Pharmacol. 1996, 48, 401.

20. S. Freeman, J. M. Gardiner "Acyclic Nucleosides as Antiviral Compounds" Molecular Biotechnology 1996, 5, 125-137.

19. J. M. Gardiner Specialist Periodical Reports, Carbohydrate Chemistry, 1996, vol. 28., Ch. 22, pp 318-332.


18. J. M. Gardiner Specialist Periodical Reports, Carbohydrate Chemistry, 1996, vol. 28., Ch. 24, pp 345-379.

17. S. Akhtar, A. Routledge, R. Patel, J. M. Gardiner "Synthesis of Mono- and Dimannoside Phosphoramidite Derivatives for Solid-Phase Conjugation to Oligonucleotides." Tetrahedron Lett. 1995, 36, 7333.

16. J. M. Gardiner, P. E. Giles "Stereoselective b-Disubstituted Enone Synthesis from g-Alkoxy- Alkynones." Tetrahedron Lett. 1995, 36, 7519.

15. J. M. Gardiner, C. R. Loyns "Synthesis of Novel 1-, 1,4- and 1,7-Substituted 2-Mercapto- and 2- Methylmercapto-Benzimidazoles: Acyclic Analogues of the HIV-1 RT Inhibitor, TIBO." Tetrahedron 1995, 51, 11515.

14. J. M. Gardiner, C. R. Loyns "Efficient one pot conversion of 6-methyl-2-nitroaniline into 1-alkoxy 2-alkyl-4-methyl-1-benzyloxy-2-phenyl-4-methyl-, and 1-allyloxy-4-methyl-2-vinyl benzimidazole." Synth. Comm. 1995, 25, 819.

13. J. M. Gardiner, C. R. Loyns, C. H. Schwalbe, G. C. Barrett, P. R. Lowe "Synthesis of 1-alkoxy-2- alkyl benzimidazoles from 2-nitroanilines viatandem N-alkylation-cyclization-O-alkylation." Tetrahedron 1995, 51, 4101.

12. J. M. Gardiner, C. R. Loyns, N. Mahmood "Synthesis and anti-HIV-1 inhibition of novel benzimidazole derivatives" Bioorg. Med. Chem. Lett. 1995, 5, 1251.

11. M. E. Jung, J. M. Gardiner "Asymmetric synthesis of Carbohydrates: Synthesis of 2-deoxy-D- and 2-deoxy-L-xylofuranosides from a simple achiral precursor." Tetrahedron Lett. 1994, 35, 6755

10. M. E. Jung, J. M. Gardiner "Synthesis of antiviral nucleosides from crotonaldehyde. Part 3. Total synthesis of didehydrodideoxythymidine (d4T)." Tetrahedron Lett. 1992, 33, 3841

9. J. M. Gardiner, C. R. Loyns "Rapid synthesis of intermediates for the synthesis of TIBO." J. Pharm. Pharmacol. 1992, 44, 1079

8. M. E. Jung, J. M. Gardiner "Synthetic approaches to 3'-azido-3'-deoxythymidine (AZT) and other modified nucleosides." J. Org. Chem. 1991, 56, 2614.

7. M. E. Jung, C. Castro, J. M. Gardiner "Rapid Synthesis of 2',3'-dideoxycytidine (ddC) from a simple achiral precursor". Tetrahedron Lett. 1991, 32, 5717.

6. J. M. Gardiner, M. R. Bryce, P. Bates, M. B. Hursthouse "Cephalotaxine analogues: Stereospecific synthesis of spirofused 3-benzazepine and 1,3-benzodiazepine derivatives." J. Org. Chem. 1990, 55, 1261.

5. M. E. Jung, I. D. Trifunovic, J. M. Gardiner, G. L. Clevenger "Preparation of modified nucleosides from glucosamine: Rapid and efficient formal total synthesis of several 2'-deoxy-C-nucleosides." J. Chem. Soc., Chem. Commun. 1990, 84.

4. M. R. Bryce, J. M. Gardiner "Functionalized (±) Cephalotaxine analogues." J. C. S., Chem. Commun. 1989, 1162.

3. M. R. Bryce, J. M. Gardiner, P. A. Horton, S. A. Smith "Synthesis and reactions of 1-azaspirocycles: 1-Azaspiro[4.5]-decane and 1-aza-spiro[4.4]nonane ring systems." J. Chem. Res.(S) 1989, 1, 1

2. M. R. Bryce, J. M. Gardiner "Stereospecific synthesis of the cyclopenta[e]phenanthridine ring system. Tetracyclic and pentacyclic analogues of Cephalotaxus alkaloids." Tetrahedron l98844, 599.

1. M. R. Bryce, J. M. Gardiner, M. B. Hursthouse, R. L. Short "A highly stereoselective synthesis of an azaspirolactam related to Cephalotaxusalkaloids." Tetrahedron Lettl98728, 577.


© 2017-19 John Gardiner

  • Twitter Social Icon
  • LinkedIn Social Icon
This site was designed with the
website builder. Create your website today.
Start Now